ДОСЛІДЖЕННЯ АНТИОКСИДАНТНОГО ПОТЕНЦІАЛУ ДЕЯКИХ ПОХІДНИХ 5-(2-БРОМ-4- ФЛУОРОФЕНІЛ)-4-ЕТИЛ-1,2,4-ТРИАЗОЛ-3-ТІОЛУ
DOI:
https://doi.org/10.32782/2226-2008-2024-5-15Ключові слова:
1,2,4-триазол, антиоксидантна активність, молекулярний докінг, DPPHАнотація
Досліджено антиоксидантну активність восьми алкільних похідних 5-(2-бром-4-флуорофеніл)-4-етил-1,2,4-триазол-3-тіолу з використанням методу молекулярного докінгу та взаємодії з 2,2-дифеніл-1-пікрилгідразилом (DPPH). За результатами дослідження молекулярний докінг показав, що сполука 3-(2-бром-4-флуорофеніл)-4-етил-5-(пентилтіо)-4Н-1,2,4-триазол має більшу енергію взаємодії з ферментом цитохром с-пероксидазою (PDB код: 2X08) порівняно з іншими сполуками цього ряду. Водночас під час дослідження антиоксидантної активності методом DPPH встановлено, що сполука 3-(2-бром-4-флуорофеніл)-4-етил-5-(гептилтіо)- 4H-1,2,4-триазол продемонструвала найвищий рівень активності. Результати свідчать про потенціал цих сполук як антиоксидантів і обґрунтовують перспективи подальших досліджень.
Посилання
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