ЗНАЧЕНИЕ СОСТОЯНИЯ СТОРОЖЕВЫХ ЛИМФАТИЧЕСКИХ УЗЛОВ ДЛЯ ОПРЕДЕЛЕНИЯ КЛИНИЧЕСКОЙ СТАДИИ ЗАБОЛЕВАНИЯ И ПЛАНИРОВАНИЯ ЛЕЧЕНИЯ
Ключові слова:
лимфатические узлы, сигнальный лимфатический узел, опухолевые клетки, лимфангиогенные факторы, лимфатические сосуды, интегрины, маркерные белки, метастазированиеАнотація
В статье проведен анализ современных представлений о молекулярных и клеточных механизмах, которые участвуют в регуляции опухольассоциированного образования новых лимфатических сосудов. В процессах становления локального иммунного ответа на антигены оседающих в сторожевых лимфатических узлах метастатических опухолевых клеток существенная роль отводится сигнальным лимфатическим узлам. Известны несколько иммуносупрессирующих механизмов, которые реализуются на различных этапах метастазирования.
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