НЕІНВАЗИВНЕ ПРЕНАТАЛЬНЕ ТЕСТУВАННЯ (NIPT) – СУЧАСНИЙ МЕТОД ПРЕНАТАЛЬНОГО СКРИНІНГУ (ОГЛЯД ЛІТЕРАТУРИ)
DOI:
https://doi.org/10.32782/2226-2008-2024-3-11Ключові слова:
позаклітинна ДНК плода, неінвазивний пренатальний тест, NIPT, пренатальний скринінг на хромосомні анеуплоїдії, імплементація NIPTАнотація
Неінвазивний пренатальний тест (NIPT) базується на дослідженні позаклітинної ДНК плода в крові вагітної жінки. Він є важливим доповненням до пренатальних скринінгових тестів на хромосомні аномалії. Тест збільшує імовірність виявлення хромосомної патології у плода й одночасно зменшує кількість необхідних інвазивних тестів. NIPT використовується як скринінговий тест і потребує за позитивних результатів підтвердження діагнозу інвазивними методами. У ряді країн NIPT передбачений у державних програмах пренатального скринінгу як тест першої або другої лінії. В Україні тест пропонується приватними лабораторіями за власні кошти пацієнтів. Використання NIPT потребує створення власних або адаптації наявних рекомендацій щодо алгоритму застосування методу, інтерпретації результатів тесту.
Посилання
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