ЛІКУВАННЯ ГОСТРИХ ТА ХРОНІЧНИХ РАН СТОП У ПАЦІЄНТІВ З ЦУКРОВИМ ДІАБЕТОМ. ОГЛЯД ОПУБЛІКОВАНИХ ДОСЛІДЖЕНЬ

Автор(и)

DOI:

https://doi.org/10.32782/2226-2008-2025-2-12

Ключові слова:

діабетична виразка стопи, гіпербарична оксигенотерапія, загоєння ран, ішемія, гіпоксія

Анотація

Метою нашого дослідження було оцінити ефективність гіпербаричної оксигенотерапії (ГБО) як допоміжного методу лікування діабетичних виразок стопи на основі огляду сучасних літературних джерел. Проведено систематичний огляд рандомізованих контрольованих досліджень, відібраних із баз даних PubMed, Cochrane та Scopus за ключовими словами, пов’язаними з ГБО і діабетичними виразками. Основними критеріями включення були наявність контрольної групи, якість дослідження та відповідність темі.Результати аналізу показали, що частина досліджень підтверджує позитивний вплив ГБО на загоєння ран, зокрема скорочення площі виразок і зниження частоти ампутацій, тоді як інші роботи не виявили суттєвих переваг. Висновок: ГБО має потенціал для покращення результатів лікування, але потрібні додаткові дослідження для більш точного підтвердження її ефективності.

Посилання

Monteiro-Soares M, Hamilton EJ, Russel DA, et al. Guidelines on the classification of foot ulcers in people with diabetes IWGDF 2023 update. 2023; 6–7. Available from: https://iwgdfguidelines.org.

Armstrong DG, Boulton AJ, Bus SA. Diabetic foot ulcers and their recurrence. New England Journal of Medicine. 2017; 376(24): 2367–2375. Available from: https://www.nejm.org/doi/full/10.1056/NEJMra1615439.

Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Annals of Medicine. 2017; 49(2): 106–116. Available from: https://www.tandfonline.com/doi/full/10.1080/ 07853890.2016.1231932.

Wagner FW. The diabetic foot: The role of ischemia and infection. In: The diabetic foot. 3rd ed. New York: Elsevier; 2011. P. 75–100. Available from: https://www.elsevier.com.

Bus SA, Sacco ICN, Monteiro-Soares M, et al. Guidelines on the prevention of foot ulcers in persons with diabetes. 2023. Available from: https://iwgdfguidelines.org/guidelines/guidelines-on-the-prevention-of-foot-ulcers-in-persons-with- diabetes/.

Stoekenbroek RM, Santema TB, Legemate DA, Ubbink DT. Hyperbaric oxygen for the treatment of diabetic foot ulcers: A systematic review. European Journal of Vascular and Endovascular Surgery. 2018; 56(2): 191–200. Available from: https://doi.org/10.1016/j.ejvs.2018.02.015.

Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plastic and Reconstructive Surgery. 2011; 127(1): 131S–141S. Available from: https://journals.lww.com/plasreconsurg/Fulltext/2011/01001/Hyperbaric_Oxygen__Its_Mechanisms_and_ Efficacy.23.aspx.

Santema TB, Stoekenbroek RM, Koelemay MJ, et al. Hyperbaric oxygen therapy in the treatment of ischemic diabetic lower-extremity ulcers: a randomized controlled trial. Diabetes Care. 2018; 41(1): 112–119. Available from: https://diabetesjournals.org/care/article/41/1/112/36696.

Faglia E, Clerici G, Caminiti M, Curci V. Influence of hyperbaric oxygen therapy on outcomes of patients with diabetic foot ulcer. Diabetes Care. 2016; 39(1): 141–147. Available from: https://doi.org/10.2337/dc15-0164.

Thom SR, Bhopale VM, Velazquez OC, Goldstein LJ. Diabetes, hyperbaric oxygen therapy, and wound healing. Undersea & Hyperbaric Medicine. 2019; 46(1): 45–60. Available from: https://doi.org/10.22462/01.02.2019.3.

Jeffcoate W, Kerr M. The costs of foot disease in diabetes in resource poor countries. Diabet Med. 2022; 39(9): e14900. Available from: https://doi.org/10.1111/dme.14900.

Andrews KL, Houdek MT, Kiemele LJ. Wound management of chronic diabetic foot ulcers: From the basics to regenerative medicine. Prosthet Orthot Int. 2015; 39(1): 29–39. Available from: https://doi.org/10.1177/0309364614534296.

Zhang Y, Lazzarini PA, McPhail SM, van Netten JJ, Armstrong DG, Pacella RE. Global disability burdens of diabetesrelated lower-extremity complications in 1990 and 2016. Diabetes Care. 2020; 43(5): 964–974. Available from: https://doi.org/10.2337/dc19-1614.

Wagner FW. The diabetic foot: The role of ischemia and infection. In: The diabetic foot. 3rd ed. New York: Elsevier; 2011. P. 75–100. Available from: https://www.elsevier.com.

Lipsky BA, Berendt AR, Cornia PB, et al. Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012; 54. Available from: https://doi.org/10.1093/cid/cis346.

Canadian Diabetes Association. A step towards good health [Internet]. Toronto (ON): The Association; 2015 [cited 2015 June]. Available from: http://www.diabetes.ca/diabetes-and-you/healthy-living-resources/foot-care/a-step-towards-good- health.

American Diabetes Association. Foot complications [Internet]. Alexandria (VA): The Association; 1995–2016 [updated 2015 May 26; cited 2015 Nov 24]. Available from: http://www.diabetes.org/living-with-diabetes/complications/foot-complications.

American Diabetes Association. Economic costs of diabetes in the US in 2012. Diabetes Care. 2013; 36: 1033–1046. Available from: https://doi.org/10.2337/dc12-2625.

Zhuo XH, Zhang P, Hoerger TJ. Lifetime Direct Medical Costs of Treating Type 2 Diabetes and Diabetic Complications. Am J Prev Med. 2013; 45: 253–261. Available from: https://doi.org/10.1016/j.amepre.2013.04.017.

Bortoletto MS, de Andrade SM, Matsuo T, et al. Risk factors for foot ulcers — a cross sectional survey from a primary care setting in Brazil. Prim Care Diabetes. 2014; 8: 71–76. Available from: https://doi.org/10.1016/j.pcd.2013.08.003.

Waaijman R, de Haart M, Arts ML, et al. Risk factors for plantar foot ulcer recurrence in neuropathic diabetic patients. Diabetes Care. 2014; 37: 1697–1705. Available from: https://doi.org/10.2337/dc13-2470.

Alavi A, Sibbald RG, Mayer D, et al. Diabetic foot ulcers: Part II. Management. J Am Acad Dermatol. 2014; 70: 21.e1–2124; quiz 21.e1–2124. Available from: https://doi.org/10.1016/j.jaad.2013.08.050.

DiPreta JA. Outpatient assessment and management of the diabetic foot. Med Clin North Am. 2014; 98: 353–373. Available from: https://doi.org/10.1016/j.mcna.2013.10.008.

Health Quality Ontario. Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers: A Health Technology Assessment. Ont Health Technol Assess Ser. 2017; 17(5): 1–142. Available from: https://pubmed.ncbi.nlm.nih.gov/28572866.

Lazzarini PA, Pacella RE, Armstrong DG, Van Netten JJ. Diabetes-related lower-extremity complications are a leading cause of the global burden of disability. Diabet Med. 2018; 35: 1297–1299. Available from: https://doi.org/10.1111/dme.13680.

Zhang Y, Lazzarini PA, McPhail SM, van Netten JJ, Armstrong DG, Pacella RE. Global disability burdens of diabetes- related lower-extremity complications in 1990 and 2016. Diabetes Care. 2020; 43(5): 964–974. Available from: https://doi.org/10.2337/dc19-1614.

Quinton T, Lazzarini P, Boyle F, Russell A, Armstrong D. How do Australian podiatrists manage patients with diabetes? The Australian diabetic foot management survey. J Foot Ankle Res. 2015; 8(1): 16. Available from: https://doi.org/10.1186/ s13047-015-0072-y.

Zhang Y, Carter HE, Lazzarini PA, et al. Cost-effectiveness of guideline-based care provision for patients with diabetes-related foot ulcers: a modelled analysis using discrete event simulation. Diabet Med. 2023; 40(1). Available from: https://doi.org/10.1111/dme.14961.

Oliveira N, Rosa P, Borges L, Dias E, Oliveira F, Cássio I. Treatment of diabetic foot complications with hyperbaric oxygen therapy: a retrospective experience. Foot Ankle Surg. 2014; 20: 140–143. Available from: https://doi.org/10.1016/ j.fas.2013.10.002.

Frykberg RG. Topical wound oxygen therapy in the treatment of chronic diabetic foot ulcers. Medicina. 2021; 57(9): 917. Available from: https://doi.org/10.3390/medicina57090917.

Rayman G, Vas P, Dhatariya K, et al. Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020; 36 (Suppl 1). Available from: https://doi.org/10.1002/dmrr.3283.

Frykberg RG, Franks PJ, Edmonds M, et al. A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen (TWO2) therapy in the treatment of chronic diabetic foot ulcers: the TWO2 study. Diabetes Care. 2020; 43(3): 616–624. Available from: https://doi.org/10.2337/dc19-0476.

Serena TE, Bullock NM, Cole W, et al. Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial. J Wound Care. 2021; 30(5): 7–14. Available from: https://doi.org/10.12968/jowc.2021.30.sup5.s7.

Wang S, Pan LF, Gao L, Qin XY, Wang JN. Randomized research on the mechanism of local oxygen therapy promoting wound healing of diabetic foot based on RNA-seq technology. Ann Palliat Med. 2021; 10(2): 973–983. Available from: https://doi.org/10.21037/apm-20-295.

He S, Liang C, Yi C, Wu M. Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 2021; 174: 108743. Available from: https://doi.org/10.1016/j.diabres.2021.108743.

Kolosovych I.V., Hanol I.V. Hemocoagulation factors of hemorrhagic complications in acute pancreatitis. Fiziologichnyi Zhurnal. 2022; 68(1): 56–61. https://doi.org/10.15407/fz68.01.056

Fedorko L, Bowen JM, Jones W, et al. Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: a prospective, double-blind, randomized controlled clinical trial. Diabetes Care. 2016; 39(3): 392–399. Available from: https://doi.org/10.2337/dc15-2001.

Löndahl M, Katzman P, Nilsson A, Hammarlund C. Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes. Diabetes Care. 2010; 33(5): 998–1003. Available from: https://doi.org/10.2337/dc09-1754.

Lipsky BA, Senneville E, Abbas ZG, et al.Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 2023; 39 (Suppl 1): e3668. Available from: https://doi.org/10.1002/ dmrr.3668.

Kolosovych I.V., Hanol I.V., Lebedieva K.O. Features of performing abdominal paracentesis in the case of complicated acute pancreatitis. Odesa Medical Journal. 2023; 2(183): 56–60. Available from: https://doi.org/10.32782/2226-2008-2023-2-10.

Petrenko O., Badziukh S., Korsa V., Kolosovych I., Tykhomyrov A. Topical Application of Autologous Plasma-Derived Plasminogen Accelerates Healing of Chronic Foot Ulcers in Type 2 Diabetes Patients. The international journal of lower extremity wounds. 2024. 15347346241256025. Advance online publication. https://doi.org/10.1177/15347346241256025.

Thom SR, Bhopale VM, Velazquez OC, Goldstein LJ. Diabetes, hyperbaric oxygen therapy, and wound healing. Undersea & Hyperbaric Medicine. 2019; 46(1): 45–60. Available from: https://doi.org/10.22462/01.02.2019.3.

Kranke P, Bennett M, Martyn-St James M, Schnabel A, Debus SE. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database of Systematic Reviews. 2020; 6: CD004123. Available from: https://doi.org/10.1002/14651858.CD004123.pub4.

Guo S, Dipietro LA. Factors affecting wound healing. Journal of Dental Research. 2017; 96(4): 372–380. Available from: https://doi.org/10.1177/0022034517698227.

Ma L, Li P, Zhang H, Shi Z. The effect of hyperbaric oxygen therapy on glycemic control in diabetic patients. Diabetes Research and Clinical Practice. 2017; 131: 180–185. Available from: https://doi.org/10.1016/j.diabres.2017.07.006.

Knighton DR, Halliday B, Hunt TK. Oxygen as an antibiotic: The effect of inspired oxygen on infection. Surgery. 2019; 105(5): 607–612. Available from: https://doi.org/10.1016/0039-6060(89)90104-5.

##submission.downloads##

Опубліковано

2025-05-16

Номер

Розділ

ОГЛЯД ЛІТЕРАТУРИ