СУЧАСНІ ПОГЛЯДИ НА ЕТІОЛОГІЧНІ ТА ПАТОГЕНЕТИЧНІ ЧИННИКИ РОЗВИТКУ Й ПЕРЕБІГУ ГЕНЕРАЛІЗОВАНОГО ПАРОДОНТИТУ
DOI:
https://doi.org/10.32782/2226-2008-2025-2-11Ключові слова:
генералізований пародонтит, етіологічні фактори, клінічний перебіг, біоплівки, мікробіомАнотація
В оглядовій статті наведені актуальні погляди на етіологічні та патогенетичні фактори розвитку й особливості клінічного перебігу генералізованого пародонтиту. Представлені результати сучасних мікробіологічних, імунологічних і біохімічних досліджень складу назубних біоплівок, ротової рідини та сироватки крові пацієнтів з ураженнями тканин пародонта порівняно з відповідними показниками осіб зі здоровим пародонтом. Описані експериментальні роботи науковців щодо особливостей перебігу пародонтиту у тварин залежно від штамів мікроорганізмів, що індукували захворювання, та змін в імунологічних і біохімічних показниках сироватки крові. Висвітлені нові біомаркери, які можна використовувати для діагностики захворювання на ранніх стадіях. У роботі зазначені перспективні методи подальшого вивчення патогенетичних особливостей пародонтиту й напрями удосконалення протоколів лікування та профілактики.
Посилання
Savielieva NM. Osoblyvosti kliniky, diahnostyky, likuvannia i profilaktyky heneralizovanoho parodontytu u khvorykh z parazytarnoiu invaziieiu [Clinical features, diagnosis, treatment, and prevention of generalized periodontitis in patients with parasitic invasion] [dissertation on the Internet]. Odesa: State Institution “Institute of Stomatology and Maxillo-facial Surgery NAMS Ukraine”; 2017. 398 p. (in Ukrainian). Available from: https://www.instom.od.ua/images/dissertations/pdf/%D0%94%D0%B8%D1%81%D0%B5%D1%80%D1%82%D0%B0%D1%86%D1%96%D1%8F-%20%D0%A1%D0%B0%D0%B2%D1%94%D0%BB%D1%8C%D1%94%D0%B2%D0%B02.pdf.
Khudan R, Krynytska I, Marushchak M, Korda M. Influence of chronic hyperhomocysteinemia on the features of bone metabolism in the case of lipopolysaccharide-induced periodontitis. Dent Med Probl. 2022; 59(2): 255–261. DOI: 10.17219/dmp/143948.
Guo J, Xu R, Liu R, et al. Association between the systemic immune inflammation index and periodontitis: a cross-sectional study. J Transl Med. 2024; 22(1): 96. DOI: 10.1186/s12967-024-04888-3.
Guo Z, Peng Y, Hu Q, Liu N, Liu Q. The relationship between leptin and periodontitis: a literature review. PeerJ. 2023; 11: e16633. DOI: 10.7717/peerj.16633.
Cecoro G, Annunziata M, Iuorio MT, Nastri L, Guida L. Periodontitis, low-grade inflammation and systemic health: a scoping review. Medicina (Kaunas). 2020; 56(6): e272. DOI: 10.3390/medicina56060272.
Ziemyte M, Lopez-Roldan A, Carda-Dieguez M, et al. Personalized antibiotic selection in periodontal treatment improves clinical and microbiological outputs. Front Cell Infect Microbiol. 2023; 13: e1307380. DOI: 10.3389/fcimb.2023.1307380.
Lamont RJ, Kuboniwa M. The polymicrobial pathogenicity of Porphyromonas gingivalis. Front Oral Health. 2024; 5: e1404917. DOI: 10.3389/froh.2024.1404917.
Barczak K, Drozdzik A, Bosiacki M, et al. CCL5’s role in periodontal disease: a narrative review. Int J Mol Sci. 2023; 24: e17332. DOI: 10.3390/ijms242417332.
Nakao R, Takatsuka A, Mandokoro K, et al. Multimodal inhibitory effect of matcha on Porphyromonas gingivalis. Microbiology Spectrum. 2024; 12: e0342623. DOI: 10.1128/spectrum.03426-23.
Regueira-Iglesias A, Suarez-Rodriguez B, Blanco-Pintos T, et al. The salivary microbiome as a diagnostic biomarker of periodontitis: a 16S multi-batch study before and after the removal of batch effects. Front Cell Infect Microbiol. 2024; 14: e1405699. DOI: 10.3389/fcimb.2024.1405699.
Ma Z, Jiang Z, Dong H, et al. Microbial communities and functional genes in periodontitis and healthy controls. Int Dent J. 2024; 74(3): 638–646. DOI: 10.1016/j.identj.2024.01.012.
Jamieson LM. Oral microbiome research – a call for equity and inclusion. Community Dent Health. 2024; 41(1): 65–66. DOI: 10.1922/CDH_IADR24JamiesonIntro02.
Kozak M, Pawlik A. The role of the oral microbiome in the development of diseases. Int J Mol Sci. 2023; 24(6): e5231. DOI: 10.3390/ijms24065231.
Mizgalska D, Malicki S, Golda A, Chruscicka-Smaga B, Potempa J. Screening and characterization of aptamers recognizing the periodontal pathogen Tannerella forsythia. FEBS open bio. 2024; 14: 498–504. DOI: 10.1002/2211-5463.13772.
Parga A, Pose-Rodriguez JM, Muras A, et al. Do concurrent peri-implantitis and periodontitis share their microbiotas? A pilot study. Dent J (Basel). 2024; 12(4): e113. DOI: 10.3390/dj12040113.
Bhandary R, Venugopalan G, Ramesh A, Tartaglia GM, Singhal I, Khijmatgar S. Microbial symphony: navigating the intri- cacies of the human oral microbiome and its impact on health. Microorganisms. 2024; 12(3): e571. DOI: 10.3390/microor- ganisms12030571.
Murai H, Kuboniwa M, Kakiuchi M, Matsumura R, Hirata Y, Amano A. Curcumin inhibits growth of Porphyromo- nas gingivalis by arrest of bacterial dipeptidyl peptidase activity. J Oral Microbiol. 2024; 16(1): e2373040. DOI: 10.1080/20002297.2024.2373040.
Luo S, Xu T, Zheng Q. Mitochondria: an emerging unavoidable link in the pathogenesis of periodontitis caused by Porphy- romonas gingivalis. Int J Mol Sci. 2024; 25(2): e737. DOI: 10.3390/ijms25020737.
Danko EM, Panto VV. Rol mikroflory porozhnyny rota u vynyknenni zakhvoriuvan tkanyn parodontu (ohliad literatury) [The role of the oral microflora in the occurrence of periodontal diseases (literature review)]. Stomatological Bulletin. 2024; 51(1): 216–220 (in Ukrainian). DOI: 10.35220/2078-8916-2024-51-1.36.
Al-Sharqi AJ, Abdulkareem A. Microbiological and salivary biomarkers successfully predict site-specific and whole-mouth outcomes of nonsurgical periodontal treatment. J Clin Med. 2024; 13(14): e4256. DOI: 10.3390/jcm13144256.
Shigeishi H, Hamada N, Kaneyasu Y, Niitani Y, Takemoto T, Ohta K. Prevalence of oral Capnocytophaga species and their association with dental plaque accumulation and periodontal inflammation in middle-aged and older people. Biomed Rep. 2024; 20(6): e99. DOI: 10.3892/br.2024.1787.
Schaffer C, Andrukhov O. The intriguing strategies of Tannerella forsythia's host interaction. Front Oral Health. 2024; 5: e1434217. DOI: 10.3389/froh.2024.1434217.
Liu S, Wang S, Zhang N, Li P. The oral microbiome and oral and upper gastrointestinal diseases. J Oral Microbiol. 2024; 16(1): e2355823. DOI: 10.1080/20002297.2024.2355823.
Rocha CM, Kawamoto D, Martins FH, et al. Experimental inoculation of Aggregatibacter actinomycetemcomitans and Streptococcus gordonii and its impact on alveolar bone loss and oral and gut microbiomes. Int J Mol Sci. 2024; 25(15): e8090. DOI: 10.3390/ijms25158090.
Mangalekar S, Sultana M, Mulay A, et al. Analysis of microbiological profiles of Indian patients with peri-implantitis and periodontitis. Bioinformation. 2024; 20(6): 615–619. DOI: 10.6026/973206300200615.
Mashchenko IS, Hudarian OO, Kucherenko TO. Klinichni, imunolohichni ta metabolichni osoblyvosti zahostrenoho i shvy- dko prohresuiuchoho variantiv heneralizovanoho parodontyta [Clinical, immunological and metabolic features of acceler- ated and quickly progressing options of generalized periodontitis]. Suchasna stomatolohiia. 2020; 4: 26–32 (in Ukrainian). DOI: 10.33295/1992-576X-2020-4-26.
Mazurek-Mochol M, Bonsmann T, Mochol M, Poniewierska-Baran A, Pawlik A. The role of interleukin 6 in periodontitis and its complications. Int J Mol Sci. 2024; 25(4): e2146. DOI: 10.3390/ijms25042146.
Relvas M, Mendes-Frias A, Goncalves M, et al. Salivary IL-1β, IL-6, and IL-10 are key biomarkers of periodontitis severity. Int J Mol Sci. 2024; 25(15): e8401. DOI: 10.3390/ijms25158401.
Relvas M, Silvestre R, Goncalves M, et al. Analysis of salivary levels of IL-1β, IL17A, OPG and RANK-L in periodontitis using the 2017 Classification of periodontal diseases – an exploratory observational study. J Clin Med. 2023; 12(3): e1003. DOI: 10.3390/jcm12031003.
Costantini E, Sinjari B, Piscopo F, et al. Evaluation of salivary cytokines and vitamin D levels in periodontopathic patients. Int J Mol Sci. 2020; 21(8): e2669. DOI: 10.3390/ijms21082669.
Zhang Y, Kang N, Xue F, et al. Evaluation of salivary biomarkers for the diagnosis of periodontitis. BMC Oral Health. 2021; 21(1): e266. DOI: 10.1186/s12903-021-01600-5.
Zhang M, Liu Y, Afzali H, Graves DT. An update on periodontal inflammation and bone loss. Front Immunol. 2024; 15: e1385436. DOI: 10.3389/fimmu.2024.1385436.
Peng S, Fu H, Li R, et al. A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy. J Nanobiotechnology. 2024; 22(1): e359. DOI: 10.1186/s12951-024-02592-4.
Dankevych-Kharchyshyn IS, Rybert YuO, Bandrivska NN. Dynamika lipidnykh ta imunolohichnykh parametriv pid chas kuratsii heneralizovanoho parodontytu pochatkovoho – I stupenia u khvorykh na ateroskleroz [Dynamics of lipid and immu- nological parameters during the management of generalised periodontitis of the initial stage in patients with atherosclerosis]. Stomatological Bulletin. 2023; 50(4): 10–15 (in Ukrainian). DOI: 10.35220/2078-8916-2023-50-4.2.
Patil RT, Dhadse PV, Salian SS, Punse SD. Role of Oxidative Stress in Periodontal Diseases. Cureus. 2024; 16(5): e60779. DOI: 10.7759/cureus.60779.
Yang L, Fang S, Zhang R, Xia R. Associations between different triglyceride glucose index-related obesity indices and peri- odontitis: results from NHANES 2009-2014. Lipids Health Dis. 2024; 23(1): e213. DOI: 10.1186/s12944-024-02192-z.
Meng Z, Zheng W, Meng X, Xu H. The association of composite dietary antioxidant index with periodontitis in NHANES 2009-2014. Front Immunol. 2024; 15: e1384272. DOI: 10.3389/fimmu.2024.1384272.
Xu J, Zhang R, Lin S, et al. Association between periodontitis with the all-cause and cause specific mortality among the population with hyperlipidemia. BMC Oral Health. 2024; 24(1): e1246. DOI: 10.1186/s12903-024-05055-2.
Chen Y, Jin X, Wang Q, Hu S, Huang X. Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study. BMC Oral Health. 2024; 24(1): e806. DOI: 10.1186/s12903-024-04592-0.
Ma KS, Chiang CH, Chen ST, et al. Periodontitis is an immune-related adverse event associated with immune checkpoint inhibitors: A multi-center cohort study. Cancer Lett. 2024; 598: e217100. DOI: 10.1016/j.canlet.2024.217100.
Shen Z, Zhang R, Huang Y., et al. The spatial transcriptomic landscape of human gingiva in health and periodontitis. Sci China Life Sci. 2024; 67(4): 720–732. DOI: 10.1007/s11427-023-2467-1.
Cao R, Li C, Geng F, Pan Y. J-shaped association between systemic immune-inflammation index and periodontitis: Results from NHANES 2009-2014. J Periodontol. 2024; 95(4): 397–406. DOI: 10.1002/JPER.23-0260.
Bi J, Mo C, Li S, et al. High concentrations of NaF aggravate periodontitis by promoting M1 polarization in macrophages. Int Immunopharmacol. 2024; 140: e112830. DOI: 10.1016/j.intimp.2024.112830.
Neurath N, Kesting M. Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets. Front Immunol. 2024; 15: e1435054. DOI: 10.3389/fimmu.2024.1435054.
Ren Z, Xue Y, Zhang H, et al. Systemic immune-inflammation index and systemic inflammation response index are asso- ciated with periodontitis: evidence from NHANES 2009 to 2014. Int Dent J. 2024; 74(5): 1033–1043. DOI: 10.1016/j.identj.2024.03.019.
Benahmed AG, Tippairote T, Gasmi A, et al. Periodontitis continuum: antecedents, triggers, mediators, and treatment strate- gies. Curr Med Chem. 2024; 31(41): 6775–6800. DOI: 10.2174/0109298673265862231020051338.
Wei X, Qian S, Yang Y, Mo J. Microbiome-based therapies for periodontitis and peri-implantitis. Oral Dis. 2024; 30(5): 2838–2857. DOI: 10.1111/odi.14782.
Chen H, Peng L, Wang Z, He Y, Zhang X. Exploring the causal relationship between periodontitis and gut microbiome: Unveiling the oral-gut and gut-oral axes through bidirectional Mendelian randomization. J Clin Periodontol. 2024; 51(4): 417–430. DOI: 10.1111/jcpe.13906.
Razzouk S. Single-cell sequencing, spatial transcriptome ad periodontitis: rethink pathogenesis and classification. Oral Dis. 2024; 30(5): 2771–2783. DOI: 10.1111/odi.14761.
Baima G, Ferrocino I, Del Lupo V, et al. Effect of periodontitis and periodontal therapy on oral and gut microbiota. J Dent Res. 2024; 103(4): 359–368. DOI: 10.1177/00220345231222800.
