MORPHOLOGICAL CHANGES IN THE LIVER OF RATS OF BOTH SEXES WITH FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE
DOI:
https://doi.org/10.32782/2226-2008-2024-2-2Keywords:
liver, nonalcoholic fatty liver disease, fructose, rats, sex, morphological changes.Abstract
The aim of study is to make a comparative analysis of structural changes in the liver rats of both sexes, which consumed 20% fructose solution instead of water for 2 months (after that they drank water for 2 months) and for 4 months. Materials and methods: 72 white Wistar rats of both sexes were used in experiments. The age of the animals at the beginning of the research was 3.5–4 months. Rats were removed from of the experiment at the age of 7.5–8 months. The animals were divided into 3 groups: 1 – control, 2 – fructose-induced nonalcoholic fatty liver disease 2 months (after that they drank water for 2 months), 3 – fructose-induced nonalcoholic fatty liver disease 4 months. Fructose-induced nonalcoholic fatty liver disease in rats was induced by 20% fructose solution during 2 months (after that they drank water during 2 months) and 4 months. The development of nonalcoholic fatty liver disease was confirmed morphologically. Results. Long-term use of a 20% fructose solution causes changes in lipid metabolism in the body of experimental animals, which is characterized by the development of fatty liver disease. Violation of the liver structure is more pronounced when consuming fructose for 4 months as compared to drinking fructose for 2 months with 2 months of rest. In female rats, compared to male ones, structural changes of the hepatic parenchyma (the volume of the affected areas and the degree of severity of changes in them) are significantly more evident in both terms of the study.
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