METABOLIC STATE OF BONE TISSUE IN PATIENTS WITH PERIODONTAL TISSUE DISEASES
DOI:
https://doi.org/10.32782/2226-2008-2024-2-5Keywords:
periodontium, bone tissue, bone metabolism, osteocalcin, vitamin D3.Abstract
Introduction. Pathological processes in the bone component of the periodontium associated with the systemic loss of mineral density of bone tissue contribute to the destruction of alveolar septa, premature tooth loss, and disruption of the dento-alveolar apparatus. Research goal is to study the bone tissue metabolism in patients with periodontal tissue diseases and low skeletal mineral density. Research methods. Examination of 242 people aged 18–60: 116 (47,93 %) – men and 126 (52,07%) – female. Females, in turn, were divided into 2 groups: 1st group – 61 women (48,41%) in reproductive period aged from 18 to 49 years; 2nd group – 65 women (51,59%) aged from 50 to 60 in the postmenopausal period. The content of osteocalcin, vitamin D3, and C-terminal telopeptide in the blood and deoxypyridinoline in the urine was assessed in the metabolism of bone tissue. Research results and discussion. It was established that upon “normal” and “osteopenic” bone mineral density, the blood values of osteocalcin, vitamin D3, C-terminal telopeptide of human collagen type I did not differ statistically in men and women with generalized periodontitis, р>0.05. At the same time, in all states of bone mineral density, the level of deoxypyridinoline in women’s urine was, on average, 50.28% higher than that of men, р<0.05. With the increase in the intensification of dystrophic and inflammatory processes in the periodontal tissues, there was a tendency for the deterioration of the values of the parameters analyzed in the blood and urine of the examined patients, which were especially pronounced in women with generalized periodontitis in the postmenopausal period. Conclusions. Based on the research carried out on male and female patients suffering from generalized periodontitis, certain aspects of the changes in bone metabolism markers were identified. These changes were found to be dependent on factors such as gender, bone tissue mineral density, and the severity of the generalized periodontitis.
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