MODERN VIEWS ON METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS
DOI:
https://doi.org/10.32782/2226-2008-2024-2-10Keywords:
metabolic syndrome, obesity, diabetes mellitus, children, adolescents, treatment of metabolic syndrome.Abstract
Introduction. Historically, metabolic syndrome has emerged as a concept rather than a diagnosis and has been described by several other names over the years. The research aim is to find out the latest views and approaches to the management of metabolic syndrome in children. Materials and methods. Information from scientific sources, such as PubMeD, Medscape, Researchgate, and V. I. Vernadskyi National Library of Ukraine, was used to identify the latest views on metabolic syndrome in children. Results. Obesity is an integral component of metabolic syndrome and the possible development of type 2 diabetes and cardiovascular disease. This is evident in the strong association between obesity and the prevalence of metabolic syndrome and insulin resistance. The integration of waist measurements is believed to improve cardiometabolic risk stratification among children, suggesting that waist measurements should be considered in routine paediatric screening. Discussion. Weight loss in obese children and adolescents after comprehensive non-surgical interventions, including diet, physical activity, education and behavioural therapy, is associated with improvements in several metabolic parameters such as lipid profile and blood pressure. The US Food and Drug Administration (FDA) has approved pharmacotherapy for obese children and adolescents that should be considered after an intensive lifestyle change programme has failed to reduce body weight, namely liraglutide and simaglutide. Practitioners should note that in Ukraine, liraglutide is now registered for children over 12 years of age, and semaglutide is registered for adults over 18 years of age. Other weight-loss medications for adults are still being studied for the use by children and represent a wide range of future possibilities. Conclusions. It is essential that practitioners of any speciality identify patients at risk and provide guidance on the prevention and treatment of metabolic syndrome.
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