MONITORING OF CYTOTOXIN – METHYLGLYOXAL AS A MARKER OF THE PATHOGENESIS OF ACUTE PYELONEPHRITIS IN DIABETES MELLITUS
DOI:
https://doi.org/10.32782/2226-2008-2025-1-1Keywords:
pyelonephritis, diabetes mellitus, eicosanoids, oxidative stress, energy metabolism, nephroprotectionAbstract
Introduction. Acute inflammatory diseases of the organs of the urinary system, complicated by concomitant diabetes given their increasing prevalence, severity of the course, and uncertainty of the prognosis, are urgent medical and social problems today. It was established that the development of a hyperglycemic state is accompanied by a significant increase in the content of the highly reactive dicarbonyl compound methylglyoxal, which plays an important role in the pathogenesis of vascular and kidney diseases. The aim of the work is to study the correlation between the level of a marker of early protein glycolysis processes – methylglyoxal, the activity of pro-inflammatory factors, indicators of energy metabolism and pro-antioxidant status in the kidneys with pyelonephritis and accompanying diabetes under conditions of drug exposure in the experiment. Сonclusion. The obtained results indicate the presence of a pronounced positive correlation between methylglyoxal, a marker of the early processes of glycolysis of proteins, the level of eicosanoids prostaglandin E2 and leukotriene B4, of carbonyl protein groups and the activity of prooxidant enzymes xanthine oxidase and NADPH oxidase, which indicates their pathogenetic role in the development of acute inflammatory process in the kidneys of rats, especially with accompanying diabetes. A significant role in the progression of the inflammatory process in the kidneys with the hyperglycemic state, taking into account the presence of reliably significant correlations, is played by the depletion of thiol status and energy potential under conditions of oxidative/carbonyl stress development. The conducted correlation analysis showed the high efficiency of the use of etiotropic-pathogenetic medicinal effects in order to correct complex metabolic disorders in the kidneys of rats with acute pyelonephritis under hyperglycemic conditions and realize the nephroprotection effect.
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