CHARACTERISTICS OF DERMAL BLOOD CIRCULATION AND SKIN MICROBIOCENOSIS IN PATIENTS WITH LICHEN PLANUS AND RATIONALE FOR OPTIMIZED THERAPY OF THIS DERMATOSIS
DOI:
https://doi.org/10.32782/2226-2008-2026-1-10Keywords:
lichen planus, dermal microcirculation, skin microbiocenosisAbstract
Introduction. The unclear etiology, complex pathogenetic mechanisms of lichen planus (LP) emphasize the necessity for further investigation into specific triggering factors – in particular, disturbances in dermal microcirculation and skin microbiocenosis – which play a significant role in the manifestation of this dermatosis and may contribute to the optimization of therapeutic strategies. The aim of the study was to assess the functional state of dermal microcirculation and skin microbiocenosis in patients with different clinical forms of lichen planus. Materials and methods. The study included 91 patients with LP (59 women and 32 men), aged 21–65 years. The typical form of LP was diagnosed in 69 patients (75.8 %), the hypertrophic form in 12(13.2 %), and the pigmentary form in 10(11.0 %). The functional state of dermal microcirculation was assessed using laser Doppler flowmetry. Bacteriological (culture-based) analysis of the skin microbiota was also performed, sampling from both lesional and unaffected skin, with enumeration and identification of microbial colonies. Results. Patients with typical, hypertrophic, and pigmentary forms of LP exhibited a stagnant-stasis type of circulation in affected areas and a spastic type in visually unaffected areas. Microbiological analysis of LP lesions revealed polymicrobial colonization, while unaffected skin areas predominantly showed colonization by two microbial species. These findings underscore the significance of dermal microcirculation disorders and altered skin microbiocenosis in the pathogenesis of LP. Conclusions. Optimization of therapy in patients with LP – particularly through targeted correction of dermal microcirculation impairments and individualized antibiotic therapy aimed at restoring the normal skin microbiota – can enhance the effectiveness of treatment.
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