МЕТАБОЛІЧНИЙ СИНДРОМ, ДИСЛІПОПРОТЕЇНЕМІЇ І МЕЛАТОНІН
DOI:
https://doi.org/10.32782/2226-2008-2024-2-9Ключові слова:
метаболічний синдром, ожиріння, дисліпопротеїнемії, мелатонін.Анотація
Метаболічний синдром (МС) – це сукупність факторів ризику серцево-судинних захворювань, зокрема ожиріння, дисліпопротеїнемій, хронічного запалення низької інтенсивності, оксидантного стресу, інсулінової резистентності. Отже, для успішного лікування МС необхідний потенційний допоміжний лікарський засіб, який володіє антагоністичними ефектами на тригерні фактори МС. Дефіцит вироблення мелатоніну (МЕЛ) або порушення експресії рецепторів нейрогормону пов’язані з ожирінням, артеріальною гіпертензією, цукровим діабетом 2-го типу. Зокрема, існує значущий взаємозв’язок між рівнями МЕЛ та інсуліну у пацієнтів з МС, а також між співвідношенням МЕЛ/інсулін та змінами ліпідного профілю крові. Особлива увага в огляді приділена опису особливостей механізмів дії МЕЛ на ліпідний обмін, а також аналізу доказів експериментальних і клінічних випробувань МЕЛ.
Посилання
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