PROEPILEPTOGENIC EFFECTS OF SILVER NANOPARTICLES ON PENTYLENETETRAZOL-INDUCED KINDLING
Keywords:
pentylenetetrazol, kindling, silver nanoparticles, epileptic activityAbstract
On the model of pentylenetetrazol (PTZ)-induced kindling in Wistar rats the net reduction of ED50 dosage of PTZ, which was able to induce clonic seizures in 50% of experimental animals caused by silver nanoparticles was established. This effect was more pronounced in postponed period of kindling and was followed by intensification of electrographic epileptiform manifestations. Silver argentum nanoparticles influence on chronic seizure activity was determined in conditions of chronic experiment. Authors concluded that argentum nanoparticles are responsible for seizure activity enhancening.
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