THE ROLE OF MICRORNA AS BIOMARKERS OF HEREDITARY DISEASES
Keywords:
microRNA, biomarkers, neurodegenerative diseasesAbstract
Numerous microRNAs take an active part in the development of the whole organism and can cause the development of certain diseases. In the review, we touched on the role of microRNA in diseases such as: Huntington’s disease, Pendred’s syndrome, muscular dystrophy, Down’s syndrome, keratoconus. Obviously, the functions of new microRNAs in the methylation of various genes, the interaction of RNARNA characterizes the lag in mental and physical development and can serve as new biomarkers in the early diagnosis of hereditary genesis.
References
Кайдашев И. П. Перспективы изучения и применения микроРНК в иммунологии и аллергологии / И. П. Кайдашев // Клиническая иммунология. Аллергология. Инфектология. – 2008. – № 7/8 (18/19).
Кленов М. С. Формирование гетерохроматина: роль коротких РНК и метилирования ДНК / М. С. Кленов, В. А. Гвоздев // Биохимия. – 2005. – Т. 70, вып. 11. – С. 1445–1458.
Кучер А. Н. Роль микроРНК, генов их биогенеза и функционирования в развитии патологических состояний у человека / А. Н. Кучер, Н. П. Бабушкина // Медицинская генетика. – 2011. – № 1. – С. 3–13.
МикроРНК, эволюция и рак / Н. Н. Колесников, С. Е. Титов, Ю. А. Веряскина [и др.] // Цитология. – 2013. – Т. 55, № 3. – С. 159–164.
Наследственные синдромы и медико-генетическое консультирование. Атлас-справочник / С. И. Козлова, Н. С. Демикова, Е. Семанова, О. Е. Блинникова. – 2-е изд., перераб. и доп. – М. : Практика, 1996. – 392 с.
Пішак В. П. Спадкові синдроми з основами фенотипової діагностики / В. П. Пішак, В. Ф. Мислицький, С. С. Ткачук. – Чернівці : Медуніверситет, 2010. – 608 с.
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3’UTR evolution / A. Stark, J. Brennecke, N. Bushati [et al.] // Cell. – 2005. – Vol. 123. – P. 1133–1146. doi:10.1016/j.cell.2005.11.023.
Bartel D. P. MicroRNAs: genomics, biogenesis, mechanism, and function / D. P. Bartel // Cell. – 2004. – Vol. 116. – P. 281–297. doi: http://dx.doi.org/10.1016/S0092-8674(04)00045-5.
Bartel D. R. MicroRNAs: target recognition and regulatory functions / D. R. Bartel // Cell. – 2009. – Vol. 136, N 2. – P. 215–233. doi: 10.1016/j.cell.2009.01.002.
Baskerville S. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes / S. Baskerville, D. P. Bartel // RNA. – 2005. – Vol. 11, N 3. – P. 241–247. doi:10.1261/rna.7240905.
Castillo P. E. Long-term synaptic plasticity at inhibitory synapses / P. E. Castillo, Q. C. Chiu, R. C. Carroll // Curr. Opin. Neurobiol. – 2011. – Vol. 21, N 2. – P. 328–338. doi: 10.1016/j.conb.2011.01.006
Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains / D. E. Kuhn, G. J. Nuovo, A. V. Terry [et al.] // J. Biol. Chem. – 2010. – Vol. 285, N 2. – P. 1529–1543. doi: 10.1074/jbc.M109.033407.
Combinatorial microRNA target predictions / A. Krek, D. Grun, M. N. Poy [et al.] // Nat. Genet. – 2005. – Vol. 37, N 5. – P. 495–500. doi:10.1038/ng1536.
Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia / S. Greco, M. De Simone, C. Colussi [et al.] // FASEB J. – 2009. – Vol. 23, N 10. – P. 3335–3346. doi: 10.1096/fj.08-128579.
Down syndrome: searching for the genetic culprits / E. Lana-Elola, S. D. Watson-Scales, E. M. Fisher, V. L. Tybulewicz // Dis Model Mech. – 2011. – Vol. 4, N 5. – P. 586–595. doi: 10.1242/dmm.008078.
Fabian M. R. The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC / M. R. Fabian, N. Sonenberg // Nat. Struct. Mol. Biol. – 2012. – Vol. 19, N 6. – P. 586–593. doi: 10.1038/nsmb.2296.
Grosshans H. Molecular biology: the expanding world of small RNAs / H. Grosshans, W. Filipowicz // Nature. – 2008. – Vol. 451 (7177). – P. 414–416. doi: 10.1038/451414a.
Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3’ untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes / P. Sethupathy, C. Borel, M. Gagnebin [et al.] // Am. J. Hum. Genet. – 2007. – Vol. 81, N 2. – P. 405–413.
Identification of mammalian microRNA host genes and transcription units / A. Rodriguez, S. Griffiths-Jones, J. L. Ashurst, A. Bradley // Genome Res. – 2004. – Vol. 14. – P. 1902–1910. doi:10.1101/gr.2722704.
Identification of novel argonaute-associated proteins / G. Meister, M. Landthaler, L. Peters [et al.] // Curr. Biol. – 2005. – Vol. 15, N 23. – P. 2149–2155.
Jaskiewicz L. Role of Dicer in posttranscriptional RNA silencing / L. Jaskiewicz, W. Filipowicz // Curr. Top. Microbiol. Immunol. – 2008. – Vol. 320. – P. 77–97.
Kaur P. Micro RNAs in neurotoxicity / P. Kaur, A. Armugam, K. Jeyaseelan // J. of Toxicology. – 2012. – Article ID 870150, 15 pages. Published online 2012 Mar 6. doi: 10.1155/2012/870150.
Kim V. N. Biogenesis of small RNAs in animals / V. N. Kim, J. Han, M. C. Siomi // Nat. Rev. Mol. Cell. Biol. – 2009. – Vol. 10, N 2. – P. 126–139. doi: 10.1038/nrm2632.
Lee R. S. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 / R. C. Lee, R. L. Feinbaum, V. Ambros // Cell. – 1993. – Vol. 75, N 5. – P. 843–854.
Lewis B. P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are micro-RNA targets / B. P. Lewis, C. B. Burge, D. P. Bartel // Cell. – 2005. – Vol. 120, N 1. – P. 15–20. doi: 10.1016/j.cell.2004.12.035.
Mammalian microRNAs predominantly act to decrease target mRNA levels / H. Guo, N. T. Ingolia, J. S. Weissman, D. P. Bartel // Nature. – 2010. – Vol. 466 (7308). – P. 835–840. doi: 10.1038/nature09267.
MicroRNA-373 induces expression of genes with complementary promoter sequences / R. F. Place, L. C. Li, D. Pookot [et al.] // Proc. Natl. Acad. Sci USA. – 2008. – Vol. 105, N 5. – P. 1608–1613. doi: 10.1073/pnas.0707594105.
MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells / L. Sinkkonen, T. Hugenschmidt, P. Berninger [et al.] // Nat. Struct. Mol. Biol. – 2008. – Vol. 15, N 3. – P. 259–267. doi: 10.1038/nsmb.1391. Epub 2008 Mar 2.
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia / J.-H. Klusmann, Z. Li, K. Böhmer [et al.] // Genes. Dev. – 2010. – Vol. 24, N 5. – P. 478–490. doi: 10.1101/gad.1856210.
miRBase: tools for microRNA genomics / S. Griffiths-Jones, H. K. Saini, S. van Dongen, A. J. Enright // Nucleic Acids Res. – 2008. – Vol. 36. – Suppl 1. – P. 154–158.
miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes / P. W. C. Hsu, H. D. Huang, S. D. Hsu [et al.] // Nucleic acids res. – 2006. – Vol. 34. – Suppl 1. – P. 135–139. doi: https://doi.org/10.1093/nar/gkj135.
Misha P. J. MicroRNA polymorphisms: a giant leap towards personalized medicine / P. J. Misha // Per. Med. – 2009. – Vol. 6, N 2. – P. 119–125. DOI: 10.2217/17410541.6.2.119.
Most mammalian mRNAs are conserved targets of microRNAs / R. C. Friedman, K. K. Farh, C. B. Burge, D. P. Bartel // Genome Res. – 2009. – Vol. 19, N 1. – P. 92–105. doi: 10.1101/gr.082701.108. Epub 2008 Oct 27.
Mutation Altering the miR-184 Seed Region Causes Familial Keratoconus with Cataract / A. E. Hughes, D. T. Bradley, M. Campbell [et al.] // Am J Hum Genet. – 2011. – Vol. 89, N 5. – P. 628–633. doi: 10.1016/j.ajhg.2011.09.014.
Rajewsky N. microRNA target predictions in animals / N. Rajewsky // Nature Genetics. – 2006. – Vol. 38. – P. 8–13. doi: 10.1038/ng1798
RISC assembly defects in the Drosophila RNAi mutant armitage / Y. Tomari, T. Du, B. Haley [et al.] // Cell. – 2004. – Vol. 116, N 6. – P. 831–841.
Sayed D. MicroRNAs in development and disease / D. Sayed, M. Abdellatif // Physiol. Rev. – 2011. – Vol. 91, N 3. – P. 827–887. doi: 10.1152/physrev.00006.2010.
The impact of microRNAs on protein output / D. Baek, J. Villen, C. Shin [et al.] // Nature. – 2008. – Vol. 455 (7209). – P. 64–71. doi: 10.1038/nature07242.
The Microprocessor complex mediates the genesis of microRNAs / R. I. Gregory, K. P. Yan, G. Amuthan [et al.] // Nature. – 2004. – Vol. 432. – P. 235–240. doi: 10.1038/nature03120.
The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington’s dis ease / A. N. Packer, Y. Xing, S. Q. Harper [et al.] // J. Neurosci. – 2008. – Vol. 28, N 53. – P. 14341–14346. doi: 10.1523/JNEUROSCI.2390-08.2008.
The role of microRNA in nutritional control / E. N. Nolte-’t Hoen, E. Van Rooij, M. Bushell [et al.] // J. Intern. Med. – 2015. – Vol. 278, N 2. – P. 99–109. doi: 10.1111/joim.12372.
Thomson D. W. Experimental strategies for microRNA target identification / D. W. Thomson, C. P. Bracken, G. J. Goodall // Nucleic Acids Res. – 2011. – Vol. 39, N 16. – P. 6845–6853. doi: 10.1093/nar/gkr330. Epub 2011 Jun 7.
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overex-pression of alpha-synuclein / G. Wang, J. M. van der Walt, G. Mayhew [et al.] // Am. J. Hum. Genet. – 2008. – Vol. 82, N 2. – P. 283–289. doi: 10.1016/j.ajhg.2007.09.021.
Weinberg M. S. Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics / M. S. Weinberg, M. J. Wood // Hum. Mol. Genet. – 2009. – Vol. 18, N R1. – P. R27–R39. doi: 10.1093/hmg/ddp070.
Widespread changes in protein synthesis induced by micro-RNAs / M. Selbach, B. Schwanhäusser, N. Thierfelder [et al.] // Nature. – 2008. – Vol. 455 (7209). – P. 58–63. doi: 10.1038/nature07228.
Wightman B. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans / B. Wightman, I. Ha, G. Ruvkun // Cell. – 1993. – Vol. 75, N 5. – P. 855–862.
