THE INFLUENCE OF INTERLEIKIN-1-ANTAGONIST OF KINDLING-INDUCED CONVULSIVE ACTIVITY
Keywords:
kindling, picrotoxin, interleukin-1, interleukin-1 receptor recombinant antagonist, cytokines, pathogenetic mechanisms, dysregulative pathologyAbstract
The data of the experimental trial are given showing the influence of interleukin-1-beta (IL-1) receptors block using IL-1 receptors antagonist (IL-1ra) on kindling-induced seizures. IL-1 receptors block reveals anticonvulsant effect under conditions of picrotoxin-induced kindling. IL-1ra delays kindling development. The conclusion was done about the cytokines pathogenetic importance in epileptogenesis as well as about the chronic convulsive syndrome pathophysiologic mechanisms accenting on neural and immune systems pathological dysregulative integration development.
References
Вастьянов Р. С. Вираженість гострих генералізованих судом за умов бокади інтерлейкін-1-бета рецепторів / Р. С. Вастьянов, Ю. С. Стрельнікова // Biomedical and Biosocial Anthropology. – 2015. – № 25. – С. 76–81.
Крыжановский Г. Н. Детерминантные структуры в патологии нервной системы / Г. Н. Крыжановский. – М. : Медицина, 1980. – 358 с.
Крыжановский Г. Н. Фундаментальные механизмы и общие закономерности дизрегуляционной патологии нервной системы / Г. Н. Крыжановский // Дизрегуляционная патология нервной системы / под ред. Е. И. Гусева, Г. Н. Крыжановского. – М. : ООО «Медицинское информационное агентство», 2009. – С. 19–192.
Шандра А. А. Киндлинг и эпилептическая активность / А. А. Шандра, Л. С. Годлевский, А. И. Брусенцов. – Одесса : Астропринт, 1999. – 191 с.
Allan S. M. Cytokines and acute neurodegeneration / S. M. Allan, N. J. Rothwell // Nat. Rev. Neurosci. – 2001. – Vol. 2. – P. 734–744.
Cytokines and absence seizures in a genetic rat model / G. van Luijtelaar, S. Lyashenko, R. Vastyanov [et al.] // Neurophysiology. – 2012. – Vol. 43, N 6. – P. 478–486.
Expressions of brain-derived neurotrophic factor (BDNF) in cerebrospinal fluid and plasma of children with meningitis and encephalitis/encephalopathy / S. Morichi, Y. Kashiwagi, K. Takekuma [et al.] // Int. J. Neurosci. – 2013. – Vol. 123, N 1. – P. 17–23.
ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy / A. Vezzani, S. Balosso, M. Maroso [et al.] // Curr. Opin. Investig. Drugs. – 2010. – Vol. 11, N 1. – P. 43–50.
Matikainen S. Role of cytokines and their blocking in immune-mediated inflammatory diseases / S. Matikainen, S. Jokiranta, K. K. Eklund // Duodecim. – 2016. – Vol. 132, N 4. – P. 349–354.
Monje M. L. Inflammatory blockade restores adult hippocampal neurogenesis / M. L. Monje, H. Toda, T. D. Palmer // Science. – 2003. – Vol. 302. – P. 1689–1690.
Schobitz B. Gene expression and function of interleukin-1, interleukin-6 and tumornecrosis factor in the brain / B. Schobitz, E. Ron de Kloet, F. Holsboer // Prog. Neurobiol. – 1994. – Vol. 44. – P. 397–432.
TNF-alpha in cerebral cortex and cerebellum is affected by amygdalar kindling but not by stimulation of cerebellum / L. S. Godlevsky, A. A. Shandra, A. A. Oleinik [et al.] // Pol. J. Pharmacol. – 2002. – Vol. 54, N 6. – P. 655–660.
Tumani H. Biochemical markers of autoimmune diseases of the nervous system / H. Tumani, J. Brettschneider // Curr. Pharm. Des. – 2012. – Vol. 18, N 29. – P. 4556–4563.
