USE OF GRAPE POLYPHENOLS IN COMPLEX THERAPY OF OVERWEIGHT PATIENTS WITH TYPE 2 DIABETES MELLITUS
Keywords:
diabetes mellitus, excessive body weight, grape polyphenols, blood lipidsAbstract
The article focuses on efficacy of a natural farmaceutic “Vin-Vita” in the management of overweight patients with type 2 diabetes mellitus. Introduction of the product into the course of treatment including eating behavior modification, differential dosed controlled physical activity as well as hypoglycemic agents, improves blood lipid parameters, which is especially important in overweight patients with type 2 diabetes who are at major risk of developing cardiovascular disease.
References
Братусь В. В. Ожирение, инсулинорезистентность, метаболический синдром: фундаментальные и клинические аспекты / В. В. Братусь, Т. В. Талева, В. А. Шумаков. – К. : Четверта хвиля, 2009. – 416 с.
Метаболический сердечно-сосудистый синдром / Е. И. Красильникова, Я. В. Благосклонная, A. A. Быстрова [и др.] // Профилактическая и клиническая медицина. – 2010. – № 3/4. – С. 15–26.
Tabas I. Anti-inflammatory therapy in chronic disease: Challenges and opportunities / I. Tabas, C. K. Glass // Science. – 2013. – Vol. 339. – P. 166–172.
Elbassuoni E. Better association of waist circumference with insulin resistance and some cardiovascular risk factors than body mass index / E. Elbassuoni // Endocrine Regulations. – 2013. – Vol. 47, N 1. – P. 3–14.
Carollo C. Wine consumption in the mediterranean diet: Old concepts in a new sight / C. Carollo, G. Caimi // Food Nutr. Sci. – 2012. – Vol. 3. – P. 1726–1733.
Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice / C. Noll, J. Dairou, C. Ripoll [et al.] // Food and Chemical Toxicology. – 2011. – Vol. 49, N 8. – P. 1764–1769.
Величко В. И. Новые подходы в комплексном лечении детей с ожирением / В. И. Величко // Одеський медичний журнал. – 2012. – № 1 (129). – C. 27–32.
Effect of red wine consumptionon biomarkers of oxidative stress / I. C. Schrieks, R. van den Berg, A. Sierksma [et al.] // Alcohol Alcohol. – 2013. – Vol. 48. – P. 153–159.
Chuang C. C. Potential mechanisms by which polyphenolrich grapes prevent obesity-mediated inflammation and metabolic diseases / C. C. Chuang, M. K. McIntosh // Ann. Rev. Nutr. – 2011. – Vol. 31. – P. 155–176.
Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats / J. M. Del Bas, J. Fernandez-Larrea, M. Blay [et al.] // FASEB J. – 2013. – Vol. 19. – P. 479–481.
Red wine phenolic compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters (Mesocricetus auratus) / C. Auger, B. Caporiccio, N. Landrault [et al.] // J Nutr. – 2002. – Vol. 132. – P. 1207–1213.
Perumalla A. V. S. Green tea and grape seed extracts — Potential applications in food safety and quality / A. V. S. Perumalla, N. S. Hettiarachchy // Food Res. Int. – 2011. – Vol. 44. – P. 827–839.
Antioxidant complexes and lipoprotein metabolism — experience of grape extracts application under metabolic syndrome and neurogenic stress / A. L. Zagayko, A. B. Kravchenko, M. V. Voloshchenko, O. A. Krasilnikova // Lipoproteins — Role in Health and Diseases. – Croatia : InTech, 2012. – P. 445–488.
Amarowitcz R. Biological Activity of Grapevine Phenolic Compounds / R. Amarowitcz, S. Weidner // Grapevine Molecular Physiology & Biotechnology ; ed. by K. A. Roubelakis-Angelakis. – The Netherlands ; Dordrecht : Springer Science + Business Media, 2009. – P. 389–405.
Реброва О. Ю. Статистический анализ медицинских данных. Применение пакета программ Statistica / О. Ю. Реброва. – М. : МедиаСфера, 2006. – 312 с.




