CORRECTIVE EFFICACY OF NIACIN-OXY-ETHYLIDENE-DIPHOSPHONATE GERMANATE (MIGU-4) ON THE MODEL OF STREPTOZOTOCIN-INDUCED DIABETES
DOI:
https://doi.org/10.32782/2226-2008-2024-3-2Keywords:
streptozotocin, diabetes mellitus, niacin-oxy-ethylidene-diphosphonate germinate, lipids, aminotransferases, vitamin EAbstract
Background. Using organic germanium compounds is promising for developing pharmacological agents to prevent diabetes mellitus complications. The study aimed to investigate the effectiveness of niacin-oxyethylene diphosphonate germanate (MIGU-4) on hyperglycemia, insulin level, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) activities, content of proteins, bilirubin, cholesterol, triglycerides, low and high-density lipoproteins (LDL and HDL, respectively) in the blood serum of rats with STZ-induced diabetes. A separate task was to compare the effectiveness of MIGU-4 with the use of vitamin E. Materials and methods. Diabetes was induced in male Wistar rats by intraperitoneal administration of streptozotocin (65.0 mg/kg). MIGU-4 was administered intraperitoneally at 25.0 mg/kg for four weeks. Results. MIGU-4 caused a decrease in glucose levels by 50.9% and increased insulin content by 25.1% (p < 0.05) in diabetic rats. Besides, MIGU-4 restored albumin content (p < 0.05), reduced total bilirubin by 42.2%, cholesterol – by 30.6%, triglycerides – by 35.4%, LDL – by 58.6% and increased HDL by 48.4% (p < 0.05). The use of MIGU-4 reduced the activity of AST and ALT by 70,1% and 42.3% (p < 0.05). The activity of ALP and LDH was also reduced by 76.6% and 53.3% (p < 0.05). With vitamin E (100.0 mg/kg), AST and ALT activity decreased by 64.0% and 36.4% (p < 0.05) and remained higher than in control by 33.3% and 37.0%, respectively (p < 0.05). The activity of ALP and LDH decreased by 79.7% and 52.1% (p < 0.05). Conclusions. MIGU-4 restores lipid metabolism, corrects serum liver function indices, and positively affects blood glucose and protein levels in streptozotocin-induced diabetes. Its effects (25.0 mg/kg) were comparable with those caused by vitamin E (100.0 mg/kg).
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