PECULIARITIES OF BONE REMODELLING AND BONE TISSUE STATUS IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES MELLITUS
DOI:
https://doi.org/10.32782/2226-2008-2024-6-9Keywords:
diagnosis, type 2 diabetes mellitus, postmenopause, bone metabolism, vitamin DAbstract
Postmenopausal women with type 2 diabetes mellitus (T2DM) have increased bone fragility and fracture risk, despite higher bone mineral density as measured by dual-energy X-ray densitometry (DEXA). Therefore, although DEXA is a standard method for detecting decreased bone mass and osteoporosis, and given that bone fracture may be the first symptom of osteoporosis, DEXA does not reflect changes in bone metabolism. The aim of the article is to study the features of bone metabolism according to clinical and laboratory data in postmenopausal women with T2DM to identify additional markers of BMD and osteoporosis decline. Materials and methods. The study included 160 postmenopausal patients divided into two groups, group 1 – 80 women diagnosed with T2DM, group 2 – 80 women without T2DM. All patients underwent a general clinical examination, densitometry, functional assessment, and biochemical markers: glycosylated blood hemoglobin, estradiol, ionised calcium (iCa2+), 25-hydroxyvitamin D (vitamin D), total alkaline phosphatase, osteocalcin (OC), Beta-CrossLaps (bCTx), parathyroid hormone (PTH), tartrate-resistant acid phosphatase (TRAP5b) in the blood serum. Results. Postmenopausal women with type 2 diabetes mellitus have a higher risk of falls, decreased muscle strength while maintaining muscle mass, decreased bone metabolism, which is manifested by decreased bone formation parameters such as iCa2+, vitamin D and OC and decreased resorption parameters such as TRAP5b and bCTx. A negative correlation was found between glycemia levels and bone formation markers vitamin D and OC, and a negative correlation with bCTx.
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