PECULIARITIES OF FOLLMANN’S SYPHILITIC BALANOPOSTHITIS DIFFERENTIAL DIAGNOSIS

Authors

DOI:

https://doi.org/10.32782/2226-2008-2024-6-14

Keywords:

syphilis, balanoposthitis, microscopy, treponemal tests

Abstract

Syphilitic balanitis, or Follmann’s balanoposthitis, is an atypical form of primary syphilis that can mimic various diseases of the male genitourinary system. Prompt diagnosis is crucial to avoid treatment complications. The aim of the study is understanding the peculiarities of the differential diagnosis of Follmann’s syphilitic balanoposthitis. Materials and methods. The clinical presentation of syphilitic balanoposthitis of Follmann varies from erosive lesions to dense infiltration and erythematous spots. Patients complain of painful erosions and swelling of the glans penis, with regional lymphadenitis commonly observed. Differential diagnosis includes excluding other infections, such as herpes, candidiasis, allergic dermatitis, and erythroplasia of Queyrat. Laboratory diagnostics involve direct methods for detecting T. pallidum and serological tests. Treatment involves the use of benzathine benzylpenicillin or alternatives, such as doxycycline, in cases of penicillin allergy. Results. Clinical case was analyzed, features of the course, diagnostic difficulties, and treatment results were determined. Conclusions. Clinical case highlights the importance of thorough examination in detecting infection sources, especially in atypical primary syphilis with Follmann’s balanoposthitis. Due to the possible seronegative phase, a comprehensive differential diagnosis is vital to prevent misdiagnosis. Accurate diagnosis and effective treatment require detailed anamnesis, clinical examination, and appropriate serological and bacteriological tests.

References

Cubiró X, García-Pérez JN, Puig L. Follmann balanitis – an atypical form of primary cutaneous syphilis. JAMA Dermatol. 2020; 156(9): 1012. https://doi.org/10.1001/jamadermatol.2020.2275.

Cao W, Thorpe PG, O’Callaghan K, Kersh EN. Advantages and limitations of current diagnostic laboratory approaches in syphilis and congenital syphilis. Expert Rev Anti Infect Ther. 2023; 21(12): 1339–1354. doi: 10.1080/14787210.2023.2280214. PMID: 37934903; PMCID: PMC10958575.

Alsterholm M, Flytstrom I, Leifsdottir R, Faergemann J, Bergbrant IM. Frequency of bacteria, Candida and malassezia species in balanoposthitis. Acta Derm Venereol. 2008. 88(4): 331–6.

Henao-Martínez AF, Johnson SC. Diagnostic tests for syphilis: New tests and new algorithms. Neurol Clin Pract. 2014; 4(2): 114–122. doi: 10.1212/01.CPJ.0000435752.17621.48. PMID: 27606153; PMCID: PMC4999316.

Huh HJ, Chung J, Park SY, Chae SL. Comparison of Automated Treponemal and Nontreponemal Test Algorithms as First-Line Syphilis Screening Assays. Ann Lab Med. 2016; 36: 23–27. https://doi.org/10.3343/alm.2016.36.1.23.

Henao-Martínez AF, Johnson SC. Diagnostic tests for syphilis: New tests and new algorithms. Neurol Clin Pract. 2014; 4(2): 114–122. doi: 10.1212/01.CPJ.0000435752.17621.48.

Janier M, Unemo M, Dupin N, Tiplica GS, Potočnik M, Pate R. 2020 European guideline on the management of syphilis. Int J STD AIDS. 2020; 31(1): 13–14. Available from: https://iusti.org/wp-content/uploads/2020/07/Syphilis2020guideline.pdf.

Published

2025-01-30

Issue

Section

A CASE FROM MEDICAL PRACTICE