MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH COVID-19 IN CHILDREN. LITERATURE REVIEW AND CLINICAL CASES
DOI:
https://doi.org/10.32782/2226-2008-2024-1-13Keywords:
children, COVID-19, multisystem inflammatory syndromeAbstract
The purpose of the work is to familiarize with the features of the course and management tactics for childhood patients with multisystem inflammatory syndrome associated with COVID-19 (MIS-C) and illustrate them with original clinical observations. Materials and methods. Specific clinical cases with evaluation of clinical symptoms, laboratory indicators, results of additional examinations, and their dynamics. Results. Clinical cases were analyzed, features of the course, diagnostic difficulties, and treatment results were determined. Conclusions. MIS-C is a complex clinical problem that requires a multidisciplinary approach in diagnosis and treatment.
References
Bertoncelli D, Guidarini M, Della Greca A, et al. COVID19: potential cardiovascular issues in pediatric patients. Acta Biomed. 2020; 91(2):177–183. doi: 10.23750/abm.v91i2.9655. PMID: 32420942; PMCID: PMC7569665.
Davies P, Evans C, Kanthimathinathan HK, et al. Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARSCoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc Health. 2020;4(9): Р. 669–677. PMID: 32653054; PMCID: PMC7347350.
Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem inflammatory syndrome in U.S. Children and Adolescents. New England Journal of Medicine. 2020; 383 (4). Р. 334–346.PMID: 32598831; PMCID: PMC7346765.
Haleemunnissa S, Didel S, Swami MK, et al. Children and COVID19: Understanding impact on the growth trajectory of an evolving generation. Children and Youth Servies Revive. 2021; 120:105754.
Jiang L, Tang K, Levin M, et al. COVID-19 and multisystem inflammatory syndrome in children and adolescents. Lancet Infect Dis. 2020 Nov; 20(11):e276-e288. doi: 10.1016/S1473-3099(20)30651-4. Epub 2020 Aug 17. Erratum in: Lancet Infect Dis. 2022 Oct; 22(10):e279. PMID: 32818434; PMCID: PMC7431129.
Jiehao C, Jin X, Daojiong L, et al. A case series of children with 2019 novel Coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020;71(6):1547–1551. doi: 10.1093/cid/ciaa198. PMID: 32112072; PMCID: PMC7108143.
Lu X, Zhang L, Du H, et al. Chinese Pediatric Novel Coronavirus Study Team. SARS-CoV-2 Infection in Children. N Engl J Med. 2020 Apr 23; 382(17):1663–1665. doi: 10.1056/NEJMc2005073. Epub 2020 Mar 18. PMID: 32187458; PMCID: PMC7121177.
McCrindle BW, Rowley AH, Newburger JW, et al. American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Council on Epidemiology and Prevention. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017 Apr 25; 135(17):e927–e999. doi: 10.1161/CIR.0000000000000484. Epub 2017 Mar 29. Erratum in: Circulation. 2019 Jul 30; 140(5):e181-e184. PMID: 28356445.
Multisystem inflammatory syndrome (MIS-C). Information for Pediatric Healthcare Providers. Available from: https://www.cdc.gov/mis/index.html (Last accessed: January 2023).
Viner RM, Whittaker E. Kawasaki-like disease: emerging complication during the COVID-19 pandemic. Lancet. 2020 Jun 6; 395(10239):1741–1743. doi: 10.1016/S0140-6736(20)31129-6. Epub 2020 May 13. PMID: 32410759; PMCID: PMC7220168.
Wei M, Yuan J, Liu Y, et al. Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China. JAMA. 2020; 323(13):1313–1314. doi: 10.1001/jama.2020.2131. PMID: 32058570; PMCID: PMC7042807.
Xia W, Shao J, Guo Y, et al. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatr Pulmonol. 2020; 55(5):1169–1174. doi: 10.1002/ppul.24718. Epub 2020 Mar 5. PMID: 32134205; PMCID: PMC7168071.
Yasuhara J, Watanabe K, Takagi H, et al. COVID-19 and multisystem inflammatory syndrome in children: A systematic review and meta-analysis. Pediatr Pulmonol. 2021 May; 56(5):837–848. doi: 10.1002/ppul.25245. Epub 2021 Jan 11. PMID: 33428826; PMCID: PMC8013394.
Zimmermann P, Curtis N. Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections. Arch Dis Child. 2020 Dec 1:archdischild-2020-320338. doi: 10.1136/archdischild-2020-320338. Epub ahead of print. PMID: 33262177.
