THE USE OF SULODEXIDE IN THE COMPLEX TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION WITH ACCOMPANYING DIABETES IN CASE OF CORONAVIRUS DISEASE COVID-19. LITERATURE REVIEW
DOI:
https://doi.org/10.32782/2226-2008-2024-2-11Keywords:
arterial hypertension, diabetes mellitus, COVID-19, sulodexide.Abstract
Background. It was found that comorbidities in COVID-19, including arterial hypertension (AH) and diabetes mellitus (DM), may be risk factors for complications and reasons for hospitalization in intensive care units. Given the need for additional exposure to micro– and macrovascular disorders in comorbidities, the data on the use of sulodexide in such comorbid pathology in patients with COVID-19 attract attention. Aim. The purpose of the review is to assess the effectiveness of sulodexide in the complex treatment of patients with arterial hypertension with accompanying diabetes in COVID-19. Methods. The search was conducted in open databases PubMed/MEDLINE. Articles with original data, systematic reviews, metaanalyses, and Guidelines of International medical societies published before March 1, 2024 were included. Results. Combined glycosaminoglycan sulodexide demonstrated a positive effect on micr- and macrovascular disorders in patients with DM micro- and macrovascular disorders. Anticoagulant, antithrombotic action of sulodexide, its ability to induce the release of tumor necrosis factor, improve the rheological properties of blood and the function of the endothelium of vessels explains the positive clinical effects in cardiovascular diseases, in particular, in hypertension and COVID-19. The use of sulodexide in patients with COVID-19 contributed to reducing the need for hospitalization in intensive care units and the need for oxygen. Conclusions. It has been established that the use of sulodexide in the basic therapy of patients with comorbid pathology facilitates the correction of most symptoms in COVID-19 and long-term post-covid syndrome.
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